![]() Consequently, only half of Zdbf2-KO pups survived the first days after birth and those surviving were smaller. We further found that Zdbf2-KO neonates failed to fully activate hypothalamic circuits that stimulate appetite, and suffered milk deprivation and diminished circulating Insulin Growth Factor 1 (IGF-1). Here, using mouse models of loss, gain and parental inversion of expression, we report that the paternally expressed Zdbf2 gene controls neonatal growth in mice, in a dose-sensitive but parent-of-origin-independent manner. ![]() While long recognized for their role in embryonic development, imprinted genes have recently emerged as important modulators of postnatal physiology, notably through hypothalamus-driven functions. We must embrace our differences, celebrate individuality, and strive for equity for all.Genomic imprinting refers to the mono-allelic and parent-specific expression of a subset of genes. Our shared commitment to diversity, inclusion and equity is only possible through the commitment from our faculty, staff, students, and alumni. We vow to honor inclusion through the acceptance of each member’s background, ethnicity, gender identity, gender expression, sexual orientation, age, religion, physical difference, developmental difference and more. The College of Veterinary Medicine creates a community of learning that supports each individual member through respectful communication, honoring different beliefs, and practicing kindness. We are committed to a diverse, equitable, and inclusive community. As an institution we pay respect and honor to the Palus people and the nation of Nez Perce as well as all the other Indigenous communities across the region where we have campuses and programs. Washington State University Pullman campus is located on the homelands of the Nimíipuu (Nez Perce) Tribe and Palus people.
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